Highly enantioselective direct alkylation of arylacetic acids with chiral lithium amides as traceless auxiliaries

CE Stivala, A Zakarian

文献索引：Stivala, Craig E.; Zakarian, Armen Journal of the American Chemical Society, 2011 , vol. 133, # 31 p. 11936 - 11939

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被引用次数: 37

摘要

A direct, highly enantioselective alkylation of arylacetic acids via enediolates using a readily available chiral lithium amide as a stereodirecting reagent has been developed. This approach circumvents the traditional attachment and removal of chiral auxiliaries used currently for this type of transformation. The protocol is operationally simple, and the chiral reagent is readily recoverable.