Chemical Communications

The palladium-catalyzed cyanation of indole C–H bonds with the combination of NH4HCO3 and DMSO as a safe cyanide source

X Ren, J Chen, F Chen, J Cheng

文献索引：Ren, Xinyi; Chen, Jianbin; Chen, Fan; Cheng, Jiang Chemical Communications, 2011 , vol. 47, # 23 p. 6725 - 6727

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被引用次数: 120

摘要

A palladium-catalyzed cyanation of the 3-position of indole sp2 C–H bonds by the combination of NH4HCO3 and DMSO as the “CN” source was achieved to provide aromatic nitriles in moderate to good yields with excellent regioselectivity. It represents a practical and safe cyanation method.