Design and synthesis of potent and selective 5, 6-fused heterocyclic thrombin inhibitors

C Dominguez, DE Duffy, Q Han, RS Alexander…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 7 p. 925 - 930

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被引用次数: 11

摘要

... Bioorganic & Medicinal Chemistry Letters. Volume 9, Issue 7, 5 April 1999, Pages 925–930. Cover image Cover image. ... We report the design, synthesis, and antithrombotic efficacy of XU817 (7), a nonpeptide 5-(amidino) indole thrombin inhibitor. ...