Synthesis of 4-substituted 2H-naphth [1, 2-b]-1, 4-oxazines, a new class of dopamine agonists

…, DE McClure, GF Lundell, WC Randall…

文献索引：Jones; Anderson; Baldwin; Clineschmidt; McClure; Lundell; Randall; Martin; Williams; Hirshfield Journal of Medicinal Chemistry, 1984 , vol. 27, # 12 p. 1607 - 1613

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被引用次数: 66

摘要

A series of tricyclic oxazines, namely, the 4-substituted 2H-naphth [1, 2-b]-1, 4-oxazines, have been synthesized and assayed for dopamine agonist activity. One of the members of this series, compound (+) VII-16, was found to be a remarkably potent agonist in vivo when tested in the standard 6-hydroxydopamine lesioned rat assay. The absolute configuration of the compound corresponds to that found in the active isomer of apomorphine. Its activity at ...