Development of highly potent and selective diaminothiazole inhibitors of cyclin-dependent kinases

E Schonbrunn, S Betzi, R Alam, MP Martin…

文献索引：Journal of Medicinal Chemistry, , vol. 56, # 10 p. 3768 - 3782

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被引用次数: 18

摘要

... Journal of Medicinal ... Deregulation of CDKs has been associated with a number of medical conditions, and they have therefore become ... 5-yl)(phenyl)methanone (1) was selected for thorough structure–activity relationship (SAR) analysis using medicinal chemistry and protein ...