Synthesis and biological activity of the putative metabolites of the atypical antipsychotic agent tiospirone

JA Cipollina, EH Ruediger, JS New…

文献索引：Cipollina, Joseph A.; Ruediger, Edward H.; New, James S.; Wire, Mary E.; Shepherd, Timothy A.; et al. Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3316 - 3328

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被引用次数: 33

摘要

Putative oxidative metabolites of the lead antipsychotic agent tiospirone (1) were synthesized to assist in the identification of the authentic metabolic products found in human urine samples. Thus far, six authentic metabolites have been correlated to the synthetic species.'. The putative metabolites were further examined in vitro to assess their central nervous system therapeutic potential. SAR analysis of these derivatives indicates that ...