Tetrahedron

A new approach towards the synthesis of 3-amino-6-(hetero) arylpyridazines based on palladium catalyzed cross-coupling reactions

…, GLF Lemiere, R Dommisse, K Augustyns, A Haemers

文献索引：Maes, Bert U. W.; Lemiere, Guy L. F.; Dommisse, Roger; Augustyns, Koen; Haemers, Achiel Tetrahedron, 2000 , vol. 56, # 12 p. 1777 - 1781

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被引用次数: 77

摘要

The synthesis of 3-amino-6-(hetero) arylpyridazines via palladium catalyzed cross-coupling reactions (Suzuki, Stille) on 3-amino-6-chloropyridazine (1a) and 3-amino-6-iodopyridazine (1b) has been investigated. Comparison of the results shows that there is no need to start from 1b. An improved method for the synthesis of compound 1b from 1a is also described.