Synthesis of constrained ceramide analogs and their potent antileukemic activities

…, MC Hong, SW Ko, YW Kim, WK Lee, J Park

文献索引：Ha, Hyun-Joon; Hong, Myeng Chan; Ko, Seung Whan; Kim, Yong Woo; Lee, Won Koo; Park, Jungchan Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 7 p. 1880 - 1883

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被引用次数: 22

摘要

Constrained ceramide analogs were designed and synthesized by binding terminal alcohol and amine of ceramide with additional carbonyl functional group as 3-acetyl (3), 3-propionyl (4), 3-benzoyl (5), and 3-hexadecanoyl-4-(1-hydroxyhexadec-2-enyl)-oxazolidin-2-ones (6). Compounds 4 and 5 showed potent antileukemic activities against human leukemia HL-60 cells with good correlation between cell death and DNA fragmentation.