Phosphinic acid pseudopeptides analogous to glutamyl-γ-glutamate: synthesis and coupling to pteroyl azides leads to potent inhibitors of folylpoly-γ-glutamate …

N Valiaeva, D Bartley, T Konno…

文献索引：Valiaeva; Bartley; Konno; Coward Journal of Organic Chemistry, 2001 , vol. 66, # 15 p. 5146 - 5154

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被引用次数: 77

摘要

Several routes to a complex phosphinate phosphapeptide analogous to the γ-glutamyl peptide Glu-γ-Glu have been investigated. Formation of γ-phosphono glutamate derivatives via addition of a phosphorus-based radical to protected vinylglycine was found to be of limited value because of the elevated temperatures required. Alkylation and conjugate addition reactions of trivalent phosphorus (PIII) species were investigated. In situ ...