Design, construction and properties of peptide N-terminal cap templates devised to initiate α-helices. Part 2.† Caps derived from N-[(2 S)-2-chloropropionyl]-(2 S)-Pro-( …
TJ Rutherford
文献索引：Lewis, Arwel; Wilkie, John; Rutherford, Trevor J.; Gani, David Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 22 p. 3777 - 3793
Recently, we designed 12-membered macrocyclic template caps to entrain peptides into α- helical structures, based on the covalent connection of the first and fourth residues of proline containing tetrapeptides. It was not possible to complete the synthesis of the templates from the acyclic precursors and it appeared that the generation of large molecular dipoles, caused by aligning the carbonyl groups, prevented reaction. While this work was in ...
