Tetrahedron

Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides: effects of different thio-heterocyclic rings and aminoalkyl side chains

Z Li, Q Yang, X Qian

文献索引：Li, Zhigang; Yang, Qing; Qian, Xuhong Tetrahedron, 2005 , vol. 61, # 36 p. 8711 - 8717

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被引用次数: 22

摘要

Two kinds of thio-heterocyclic fused naphthalene carboxamides,,, were designed, synthesized and quantitatively evaluated as efficient antitumor and DNA photocleaving agents. Compound or, having the thiophene ring, intercalated into DNA more strongly than compound or, having the thioxanthene ring. Compound or, photocleaved DNA more efficiently than or via superoxide anion. Compound was the strongest inhibitor for P388 ( ...