At various temperatures between 50 and 110 OC, 2-aminopurine deoxyribonucleoside is severalfold more prone to degradation in aqueous sodium cacodylate buffer, pH 6.9, than is its structural isomer, deoxyadenosine, as determined by HPLC analysis of hydrolysates. It is calculated that, at 37" C, the rate of hydrolysis of 2-aminopurine deoxyribonucleoside is 5 times as large as the rate of hydrolysis of deoxyadenosine. The decomposition of 2- ...
