Microbial hydroxylation of steroids. 9. Epoxidation of Δ6-3-ketosteroids by Rhizopus arrhizus ATCC 11145, and the mechanism of the 6β hydroxylase enzyme
…, EM Thomas, B Mader, MJ Dennis
文献索引：Holland, Herbert L.; Chenchaiah, P. Chinna; Thomas, Everton M.; Mader, Beatrix; Dennis, Michael J. Canadian Journal of Chemistry, 1984 , vol. 62, p. 2740 - 2747
'The enzymic introduction of a hydroxy group at the C-6P position of A4-3-ketosteroids (the conversion of 1 to 2) is a common example of a biotransformation which can be carried out efficiently by mammalian (I) or microbial (2) systems. We have studied the latter reaction, performed by the fungus Rhizopus arrhizus, and have demonstrated that the substrate is hydroxylated in its A3,'-dienol form (eq.[I])(3-8).
