Analogues of methotrexate in rheumatoid arthritis. 2. Effects of 5-deazaaminopterin, 5, 10-dideazaaminopterin, and analogues on type II collagen-induced arthritis in …

…, JI DeGraw, WT Colwell, CA Johnson…

文献索引：Piper, James R.; DeGraw, Joseph I.; Colwell, William T.; Johnson, Cheryl A.; Smith, R. Lane; Waud, William R.; Sirotnak, Francis M. Journal of Medicinal Chemistry, 1997 , vol. 40, # 3 p. 377 - 384

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被引用次数: 23

摘要

Twenty-six compounds derived from the 5-deaza-and 5, 10-dideazaaminopterin series of aminopterin analogues were evaluated for antiarthritic activity in the mouse type II collagen model. New compounds in the 5-deaza series were prepared by alkylation of an appropriate N-substituted (4-aminobenzoyl)-l-glutamic acid dialkyl ester or N-(5-amino-2-thenoyl)-l- glutamate diester with a 2, 4-diamino-5-alkyl-6-(bromomethyl)-5-deazapteridine. The ...