Pharmacophore/receptor models for GABAA/BzR subtypes (α1β3γ2, α5β3γ2, and α6β3γ2) via a comprehensive ligand-mapping approach

…, GR Wenger, R McKernan, JM Cook

文献索引：Yu, Shu; Ma, Chunrong; He, Xiaohui; McKernan, Ruth; Cook, James M. Medicinal Chemistry Research, 1999 , vol. 9, # 2 p. 71 - 88

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被引用次数: 143

摘要

Pharmacophore/receptor models for three recombinant GABAA/BzR subtypes (α1β3γ2, α5β3γ2, and α6β3γ2) have been established via an SAR ligand-mapping approach. This study was based on the affinities of 151 BzR ligands at five distinct (α1-3, 5, 6β3γ2) recombinant GABAA/BzR receptor subtypes from at least nine different structural families. Examination of the included volumes of the α1-, α5-, and α6-containing subtypes indicated ...