Synthesis of BMS-309403-related compounds, including [14C] BMS-309403, a radioligand for adipocyte fatty acid binding protein

…, M Hiromura, M Otsuka, S Enomoto, H Miyachi

文献索引：Okada, Toshihiko; Hiromura, Makoto; Otsuka, Masato; Enomoto, Shuichi; Miyachi, Hiroyuki Chemical and Pharmaceutical Bulletin, 2012 , vol. 60, # 1 p. 164 - 168

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被引用次数: 4

摘要

Adipocyte fatty acid binding protein (A-FABP; FABP4), which is predominantly expressed in macrophages and adipose tissue, regulates fatty acid storage and lipolysis, and is also an important mediator of inflammation. Here, we report a synthesis of 14 C-labeled 2-[2′-(5- ethyl-3, 4-diphenyl-1H-pyrazol-1-yl) biphenyl-3-yloxy] acetic acid (BMS309403), a potent and selective small-molecular FABP4 inhibitor, as a chemical tool for investigating the ...