Tetrahedron letters

Isolation, structure, and synthesis of dolastatin D, a cytotoxic cyclic depsipeptide from the sea gare Dolabella auricularia

H Sone, T Nemoto, H Ishiwata, M Ojika, K Yamada

文献索引：Sone, Hiroki; Nemoto, Takayuki; Ishiwata, Hiroyuki; Ojika, Makoto; Yamada, Kiyoyuki Tetrahedron Letters, 1993 , vol. 34, # 52 p. 8449 - 8452

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被引用次数: 66

摘要

Abstract Dolastatin D (1), a cytotoxic cyclic depsipeptide possessing the novel β-amino acid (2R, 3R)-3-amino-2-methylbutanoic acid [(2R, 3R]-3] as a component, has been isolated from the Japanese sea hare Dolabella auricularia. The absolute stereostructure of 1 was elucidated on the basis of spectroscopic analysis and chemical degradation and was further confirmed by synthesis.