Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 …

K Yamauchi, T Mitsunaga, M Inagaki…

文献索引：Yamauchi, Kosei; Mitsunaga, Tohru; Inagaki, Mizuho; Suzuki, Tohru Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 13 p. 3331 - 3340

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被引用次数: 11

摘要

Abstract In order to understand the effect of structure–activity relationships on melanogenesis using B16 melanoma cells, 19 quercetin derivatives were synthesized. Among the synthesized compounds, 3-O-methylquercetin (11) and 3′, 4′, 7-O- trimethylquercetin (14) increased melanin content more potently than the positive control theophylline, while exhibiting low cytotoxicity. Compound 11 exhibited less ...