Synthetic communications

… CB1 receptor chemical affinity probes: methods suitable for preparation of isopropyl [11, 12-3H] dodecylfluorophosphonate and [11, 12-3H] dodecanesulfonyl fluoride

Y Segall, GB Quistad, JE Casida

文献索引：Segall, Yoffi; Quistad, Gary B.; Casida, John E. Synthetic Communications, 2003 , vol. 33, # 12 p. 2151 - 2159

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被引用次数: 24

摘要

Abstract Preparations of isopropyl dodec-11-enylfluorophosphonate and dodec-11- enesulfonyl fluoride are described along with conditions for their reduction with hydrogen (or potentially tritium) gas to the 1-dodecane derivatives as candidate high-potency (IC50 0.5–7 nM) chemical affinity probes for the mouse brain cannabinoid CB1 receptor and fatty acid amide hydrolase.