The rapid generation of isothiocyanates in flow

M Baumann, IR Baxendale

文献索引：Baumann, Marcus; Baxendale, Ian R. Beilstein Journal of Organic Chemistry, 2013 , vol. 9, p. 1613 - 1619

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被引用次数: 12

摘要

Abstract Isothiocyanates are versatile starting materials for a wide range of chemical reactions. However, their high nucleophilic susceptibility means they are best prepared and used immediately. We report here on a flow platform for the fast and efficient formation of isothiocyanates by the direct conversion of easily prepared chloroximes. To expedite this chemistry a flow insert cartridge containing two immobilised reagents is used to affect the ...