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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

The total synthesis of 12-HETE (12-hydroxyeicosatetraenoic acid) and 12, 20-diHETE

Y Leblanc, BJ Fitzsimmons, J Adams…

文献索引：Leblanc, Yves; Fitzsimmons, Brian J.; Adams, Julian; Perez, Francoise; Rokach, Joshua Journal of Organic Chemistry, 1986 , vol. 51, # 6 p. 789 - 793

全文：HTML全文

被引用次数: 86

摘要

2: R= CH20H 12, ZO-dlHETE arachidonic acid by a 12-lipoxygenase enzyme, which is found in platelets' and skin, keratinocytes. 2 The 12-HETE is of particular interest since it has been detected in high concentrations in psoriatic lesions3 and has been shown to possess both chemotactic and chemokinetic properties. The 12 (S)-HETE is also the major lipoxygenase-derived arachidonic acid metabolite produced by the platelet and has been ...

3-Nonynoic acid结构式

3-Nonynoic acid

~%

12-HETE结构式

non-3-ynoyl chloride结构式

non-3-ynoyl chloride

~%

12-HETE结构式

1-diazo-4-decyn-2-one结构式

1-diazo-4-decyn...

~%

12-HETE结构式

2,4-tetradecadien-8-yne-1,6-diol结构式

2,4-tetradecadi...

~%

12-HETE结构式

(2Z)-6-oxotetradeca-2,4-dien-8-ynal结构式

(2Z)-6-oxotetra...

~%

12-HETE结构式

(2Z,4E)-1-((4-methoxyphenyl)diphenylmethoxy)tetradeca-2,4-dien-8-yn-6-ol结构式

(2Z,4E)-1-((4-m...

~%

12-HETE结构式

methyl 12-[(tert-butyldiphenylsilyl)oxy]-8,10,14-eicosatrien-5-ynoate结构式

methyl 12-[(ter...

~%

12-HETE结构式

6-[(tert-butyldiphenylsilyl)oxy]-1-[diphenyl(4-methoxyphenyl)methoxy]-2,4,8-tetradecatriene结构式

6-[(tert-butyld...

~%

12-HETE结构式

6-[(tert-butyldiphenylsilyl)oxy]-1-[diphenyl(4-methoxyphenyl)methoxy]-2,4-tetradecadien-8-yne结构式

6-[(tert-butyld...

~%

12-HETE结构式

6-[(tert-butyldiphenylsilyl)oxy]-2,4,8-tetradecatrien-1-ol结构式

6-[(tert-butyld...

~%

12-HETE结构式

1-bromo-6-[(tert-butyldiphenylsilyl)oxy]-2,4,8-tetradecatriene结构式

1-bromo-6-[(ter...

~%

12-HETE结构式

methyl 12-hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoate结构式

methyl 12-hydro...

~%

12-HETE结构式

methyl 12(S)-[(tert-butyldiphenylsilyl)oxy]-5(Z),8,10(E),14(Z)-eicosatetraenoate结构式

methyl 12(S)-[(...

~%

12-HETE结构式

(S,6Z,10E,12Z,15Z)-9-hydroxy-20-methoxy-20-oxoicosa-6,10,12,15-tetraen-1-yl benzoate结构式

(S,6Z,10E,12Z,1...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

6-(triphenyl-λ5-phosphanylidene)hexanoic acid结构式

6-(triphenyl-λ5...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

3-O-(tert-butyldiphenylsilyl)-1,2-bis-O-(1-methylethylidene)-5(Z)-undecene-1,2(R),3(S),11-tetrol结构式

3-O-(tert-butyl...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

(S,Z)-9-((tert-butyldiphenylsilyl)oxy)-10-oxodec-6-en-1-yl benzoate结构式

(S,Z)-9-((tert-...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

(S,Z)-9-((tert-butyldiphenylsilyl)oxy)-9-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)non-6-enoic acid结构式

(S,Z)-9-((tert-...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

(S,6Z,10E)-9-((tert-butyldiphenylsilyl)oxy)-12-oxododeca-6,10-dien-1-yl benzoate结构式

(S,6Z,10E)-9-((...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

methyl 9-O-(tert-butyldiphenylsilyl)-10,11-bis-O-(1-methylethylidene)-9(S),10(R),11-trihydroxy-6(Z)-undecenoate结构式

methyl 9-O-(ter...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

(9S,10R,Z)-9-((tert-butyldiphenylsilyl)oxy)-10,11-dihydroxyundec-6-en-1-yl benzoate结构式

(9S,10R,Z)-9-((...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

11-O-benzoyl-3-O-(tert-butyldiphenylsilyl)-1,2-bis-O-(1-methylethylidene)-5-undecene-1,2(R),3(S),11-tetrol结构式

11-O-benzoyl-3-...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

(S,6Z,10E,12Z,15Z)-9-((tert-butyldiphenylsilyl)oxy)-20-methoxy-20-oxoicosa-6,10,12,15-tetraen-1-yl benzoate结构式

(S,6Z,10E,12Z,1...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE

(S,5Z,8Z,10E,14Z)-20-(benzoyloxy)-12-((tert-butyldiphenylsilyl)oxy)icosa-5,8,10,14-tetraenoic acid结构式

(S,5Z,8Z,10E,14...

~%

12(S),20-DiHETE结构式

12(S),20-DiHETE