A new route to the synthesis of amino acids through the mercury cyclization of chiral amidals

…, G Cardillo, C Tomasini, P Tortoreto

文献索引：Amoroso, Rosa; Cardillo, Giuliana; Tomasini, Claudia; Tortoreto, Paola Journal of Organic Chemistry, 1992 , vol. 57, # 4 p. 1082 - 1087

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被引用次数: 30

摘要

By means of the mercury cyclization of the unsaturated amidals 3a-0, obtained from the reaction of 1, 3, 5-tris-[(S)-phenylethyl] hexahydrotriazine (1) and a,@-unsaturated acyl chlorides, diastereomeric mixtures of im-idazolidin-4ones 5-8 and perihydropyrimidin-4- ones 4-10 have been synthesized and easily separated by flash, chromatography. The subsequent hydrolysis under acid conditions of the separated heterocycles affords ...