The Journal of Organic Chemistry

Regioselective Reactions of Organozinc Reagents with 2, 4-Dichloroquinoline and 5, 7-Dichloropyrazolo [1, 5-a] pyrimidine

T Shiota, T Yamamori

文献索引：Shiota, Takeshi; Yamamori, Teruo Journal of Organic Chemistry, 1999 , vol. 64, # 2 p. 453 - 457

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被引用次数: 56

摘要

Strategies for controlling the regioselective reactions between 2, 4-dichloroquinoline and organozinc reagents are described. 2, 4-Dichloroquinoline has been found to react with benzylic zinc and phenylzinc reagents in the presence of catalytic amounts of palladium complexes to exclusively give α-substituted products. Several metal salts were examined as an additive for γ-selective coupling reactions. The most effective additive for selective ...