Antineoplastic agents. 515. Synthesis of human cancer cell growth inhibitors derived from 3, 4-methylenedioxy-5, 4'-dimethoxy-3'-amino-Z-stilbene

…, MK Jung, JC Knight, E Hamel, RK Pettit

文献索引：Pettit, George R.; Anderson, Collin R.; Herald, Delbert L.; Katherine Jung; Lee, Debbie J.; Hamel, Ernest; Pettit, Robin K. Journal of Medicinal Chemistry, 2003 , vol. 46, # 4 p. 525 - 531

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被引用次数: 12

摘要

Further structure-activity relationship (SAR) exploration of 3, 4-methylenedioxy-5, 4'- dimethoxy-3'-amino-Z-stilbene (1a) derivatives resulted in the efficient synthesis of tyrosine amide hydrochloride 9, two tyrosine amide phosphate prodrugs (3a and 6), and sodium aspartate amide 11. Two additional cancer cell growth inhibitors (14 and 16) were synthesized by employing peptide coupling between amine 1a and the Dap unit of ...