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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Syntheses of NAMDA derivatives inhibiting NO production in BV-2 cells stimulated with lipopolysaccharide

JW Seo, E Srisook, HJ Son, O Hwang, YN Cha…

文献索引：Jai, Woong Seo; Srisook, Ekaruth; Hyo, Jin Son; Hwang, Onyou; Cha, Young-Nam; Dae, Yoon Chi Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 14 p. 3369 - 3373

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被引用次数: 9

摘要

Sixteen derivatives of N-acetyl-3-O-methyldopamine (NAMDA), an inhibitor of BH4 synthesis, were designed and synthesized. The ability of these derivatives to inhibit NO and BH4 production by lipopolysaccharide-stimulated BV-2 microglial cells was determined. While NAMDA at 100μM inhibited NO and BH4 production by only about 20%, its catecholamide 8, indole 23 derivative, 13, and N-acetyl tetrahydroisoquinoline 25 ...

甲醛结构式

2-甲氧基-4-(2-氨基乙基)苯酚结构式

2-甲氧基-4-(2-氨基乙基)苯酚

~70%

1,2,3,4-四氢-6-甲氧基-7-异羟基喹啉盐酸盐结构式

1,2,3,4-四氢-6-甲氧...

香草醇结构式

~%

1,2,3,4-四氢-6-甲氧基-7-异羟基喹啉盐酸盐结构式

1,2,3,4-四氢-6-甲氧...

3-甲氧基-4-羟基苯乙腈结构式

3-甲氧基-4-羟基苯乙腈

~%

1,2,3,4-四氢-6-甲氧基-7-异羟基喹啉盐酸盐结构式

1,2,3,4-四氢-6-甲氧...

4-hydroxy-3-methoxy-trans-cinnamic acid nitrile结构式

4-hydroxy-3-met...

~59%

4-(3-Aminopropyl)-2-methoxyphenol结构式

4-(3-Aminopropy...

香草醛结构式

~%

4-(3-Aminopropyl)-2-methoxyphenol结构式

4-(3-Aminopropy...

六氢吡啶结构式

高香草酸结构式

~77%

2-(4-hydroxy-3-methoxyphenyl)-1-piperidin-1-ylethanone结构式

2-(4-hydroxy-3-...

香草醇结构式

~%

2-(4-hydroxy-3-methoxyphenyl)-1-piperidin-1-ylethanone结构式

2-(4-hydroxy-3-...

3-甲氧基-4-羟基苯乙腈结构式

3-甲氧基-4-羟基苯乙腈

~%

2-(4-hydroxy-3-methoxyphenyl)-1-piperidin-1-ylethanone结构式

2-(4-hydroxy-3-...

香草醇结构式

~%

N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]formamide结构式

N-[2-(4-hydroxy...

2-甲氧基-4-(2-氨基乙基)苯酚结构式

2-甲氧基-4-(2-氨基乙基)苯酚

原甲酸三甲酯结构式

原甲酸三甲酯

~69%

N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]formamide结构式

N-[2-(4-hydroxy...

3-甲氧基-4-羟基苯乙腈结构式

3-甲氧基-4-羟基苯乙腈

~%

N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]formamide结构式

N-[2-(4-hydroxy...

3-甲氧基-4-羟基苯乙腈结构式

3-甲氧基-4-羟基苯乙腈

~74%

高香草酸结构式

1-benzyloxy-2-methoxy-5-nitro-4-(2-nitrovinyl)benzene结构式

1-benzyloxy-2-m...

~30%

6-hydroxy-5-methoxyindole结构式

6-hydroxy-5-met...

4-苄氧基-3-甲氧基苯甲醛结构式

4-苄氧基-3-甲氧基苯甲醛

~%

6-hydroxy-5-methoxyindole结构式

6-hydroxy-5-met...

4-(苄氧基)-5-甲氧基-2-硝基苯甲醛结构式

4-(苄氧基)-5-甲氧基-2...

~%

6-hydroxy-5-methoxyindole结构式

6-hydroxy-5-met...

香草醛结构式

~%

6-hydroxy-5-methoxyindole结构式

6-hydroxy-5-met...

盐酸多巴胺结构式

盐酸多巴胺

乙酸酐结构式

~87%

N-acetyldopamine结构式

N-acetyldopamine

香草醇结构式

~%

N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]acetamide结构式

N-[2-(4-hydroxy...

3-甲氧基-4-羟基苯乙腈结构式

3-甲氧基-4-羟基苯乙腈

~%

N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]acetamide结构式

N-[2-(4-hydroxy...

3-甲氧基-4-羟基苯乙腈结构式

3-甲氧基-4-羟基苯乙腈

~82%

2-甲氧基-4-(2-氨基乙基)苯酚结构式

2-甲氧基-4-(2-氨基乙基)苯酚