Bipyridine cardiotonics: the three-dimensional structures of amrinone and milrinone

…, JK Swartzendruber, ND Jones, TK Elzey…

文献索引：Robertson, David W.; Beedle, E. E.; Swartzendruber, John K.; Jones, Noel D.; Elzey, T. K.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 635 - 640

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被引用次数: 62

摘要

The cardiotonic drug milrinone (1, 6-dihydro-2-methyl-6-0~ 0-[3, 4'-bipyridine]-5-~ arbonitrile) is superior to its analogue amrinone (5-amino-[3, 4'-bipyridin]-6 (lZf)-one) by virtue of its greater potency and reduced side effect profile. We confirmed initial reports on the potencies of milrinone and amrinone and found that after intravenous administration to phenobarbital anesthetized dogs, the drugs had cumulative inotropic ED,,'s of 37 and ...