A new synthesis of 1, 2, 4-triazolin-5-ones: application to the convergent synthesis of an NK 1 antagonist

CJ Cowden, RD Wilson, BC Bishop, IF Cottrell…

文献索引：Cowden; Wilson; Bishop; Cottrell; Davies; Dolling Tetrahedron Letters, 2000 , vol. 41, # 44 p. 8661 - 8664

被引用次数: 40

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... Chlorotriazolinone 4 has been synthesised in a single step via the novel condensation of semicarbazide hydrochloride with orthoester 8. Alkylation of secondary amine 3 with compound 4 proceeds in 99% yield to afford the target NK 1 antagonist 1. ... Substance P is an undecapeptide belonging to the ...