Organic Letters

Preparation of 5-Aryl Furfurals and Aryl Thiophene-2-carboxaldehydes via Palladium-Catalyzed CC Bond Formation in Aqueous Media1

JC Bussolari, DC Rehborn

文献索引：Bussolari, Jacqueline C.; Rehborn, Diana C. Organic Letters, 1999 , vol. 1, # 7 p. 965 - 967

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被引用次数: 78

摘要

A series of 5-aryl furfurals and aryl thiophene-2-carboxaldehydes was synthesized. To this end, efficient and effective palladium-catalyzed CC bond-forming reactions were carried out at room temperature in aqueous media. This mild process allowed the cross-coupling reaction of the bromides to occur in the presence of electrophilic functional groups, which is a valuable advantage over previously reported methods.