Enantioselective hydrolysis of naproxen ethyl ester catalyzed by monoclonal antibodies

…, BH Yang, JJ Zhao, YL Wu, YY Ji, M Yeh

文献索引：Shi, Zhen-Dan; Yang, Bing-Hui; Zhao, Jing-Jing; Wu, Yu-Lin; Ji, Yong-Yong; Yeh, Ming Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 7 p. 2171 - 2175

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被引用次数: 13

摘要

This report described that a hapten of racemic phosphonate 3 designed as the mimic of the transition state of hydrolysis of naproxen ethyl ester was successfully synthesized from easily available 2-acetyl-6-methoxy-naphthalene 5. Then BALB/C mice were immunized and one of the monoclonal catalytic antibodies, N116-27, which enantioselectively accelerated the hydrolysis of the R-(−)-naproxen ethyl ester was given. The Michaelis– ...