Design and synthesis of 4-phenyl piperidine compounds targeting the mu receptor

…, E Davies, WS Miller, S Shan, KJ Valenzano…

文献索引：Chen, Zhengming; Davies, Ellen; Miller, Wendy S.; Shan, Shen; Valenzano, Kenneth J.; Kyle, Donald J. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 21 p. 5275 - 5279

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被引用次数: 8

摘要

Small molecule mu agonists based on the 4-phenyl piperidine scaffold were designed and synthesized to further investigate the therapeutic potential of loperamide analogs. The resulting compounds show excellent agonistic activity towards the human mu receptor with interesting SAR trends within the series.