Preparation of a Corticotropin-Releasing Factor Antagonist by Nucleophilic Aromatic Substitution and Copper-Mediated Ether Formation†

S Caron, NM Do, JE Sieser…

文献索引：Elliott, Mark L.; Goddard, Carl J. Synthetic Communications, 1989 , vol. 19, # 9-10 p. 1505 - 1508

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被引用次数: 16

摘要

... Volume: Page: ... Several synthetic approaches to a corticotropin-releasing factor (CRF) antagonist containing a tetrasubstituted pyridine were evaluated. ... to intermediate 6, but concerns about the stability and processability of N-oxides 3 and 5 (655 J/g with a ...