Tetrahedron letters

An azetidinium ion approach to 3-aryloxy-3-aryl-1-propanamines

P O'Brien, DW Phillips, TD Towers

文献索引：O'Brien, Peter; Phillips, David W.; Towers, Timothy D. Tetrahedron Letters, 2002 , vol. 43, # 41 p. 7333 - 7335

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被引用次数: 16

摘要

Treatment of 3-(dimethylamino)-1-phenyl-propan-1-ol with mesyl chloride and then different phenols generates a range of N, N-dimethyl-3-aryloxy-3-aryl-1-propanamines via regiospecific opening of a proposed azetidinium ion intermediate. During the rearrangement process, there was some leakage of stereochemical integrity.