Chemical Science

Flow chemistry synthesis of zolpidem, alpidem and other GABA A agonists and their biological evaluation through the use of in-line frontal affinity chromatography

L Guetzoyan, N Nikbin, IR Baxendale, SV Ley

文献索引：Guetzoyan, Lucie; Nikbin, Nikzad; Baxendale, Ian R.; Ley, Steven V. Chemical Science, 2013 , vol. 4, # 2 p. 764 - 769

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被引用次数: 44

摘要

The flow of information between chemical and biological research can present a bottleneck in pharmaceutical research. Tools that bridge these disciplines and aid information exchange have therefore clear value. Over the last few years, both synthetic chemistry and biological screening have benefited from automation, and a seamless chemistry–biology interface is now possible. We report here on the use of flow processes to perform ...