Chemoselective Hydrogenation of α, β??Unsaturated Nitriles

P Kukula, M Studer, HU Blaser

文献索引：Kukula, Pavel; Studer, Martin; Blaser, Hans-Ulrich Advanced Synthesis and Catalysis, 2004 , vol. 346, # 12 p. 1487 - 1493

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被引用次数: 47

摘要

Abstract The chemoselective hydrogenation of cinnamonitrile to 3-phenylallylamine proceeds with up to 80% selectivity at conversions of> 90% with Raney cobalt and up to 60% selectivity with Raney nickel catalysts. Best results were obtained with a doped Raney cobalt catalyst (RaCo/Cr/Ni/Fe 2724) in ammonia saturated methanol at 100 C and 80 bar. Major problems are the formation of hydrocinnamonitrile and of secondary amines, and ...