Synthesis and antitumor activities of platinum complexes of unsymmetrical alicyclic diamines as carrier ligands

…, KI Endoh, T Matsumoto, KI Akamatsu…

文献索引：Morikawa; Honda; Endoh; Matsumoto; Akamatsu; Mitsui; Koizumi Journal of Pharmaceutical Sciences, 1990 , vol. 79, # 8 p. 750 - 753

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被引用次数: 17

摘要

Abstract The synthesis and biological activities of the platinum complexes of 2- aminomethylaziridine, 2-aminomethylazetidine, 2-aminomethylpyrrolidine, and 2- aminomethylpiperidine as carrier ligands are described. The platinum complexes of 2- aminomethylazetidine and 2-aminomethylpyrrolidine are significantly effective against murine tumors. In particular, 2-aminomethylazetidine (1, 1-cyclobutanedicarboxylato) ...