Synthesis of 2-aminothiazole derivatives

SI Zav'yalov, OV Dorofeeva, EE Rumyantseva…

文献索引：Zav'yalov; Dorofeeva; Rumyantseva; Kulikova; Ezhova; Kravchenko; Zavozin Pharmaceutical Chemistry Journal, 2001 , vol. 35, # 2 p. 96 - 98

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被引用次数: 12

摘要

2-Aminothiazole derivatives were reported to possess antibacterial [1], antiviral [2], and psychotropic activity [3]. These compounds are usually obtained using a two-stage scheme, including bromination of the initial ketones in ether in the presence of AlCl3 [4] or in a MeOH– (MeO) 3 mixture [5] followed by cyclocondensation of the intermediate a-bromoketones with thiourea (I) in ethanol or methanol [4, 6, 7]. It was also reported that 2-aminothiazole ...