Tetrahedron

New strategy for the chemical synthesis of proteins

…, S Funakoshi, T Watanabe, E Murayama, A Otaka

文献索引：Yajima; Fujii; Funakoshi; Watanabe; Murayama; Otaka Tetrahedron, 1988 , vol. 44, # 3 p. 805 - 819

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被引用次数: 128

摘要

For the chemical synthesis of proteins, an efficient deprotecting procedure by combination of a hard acid, trimethylsilyl trifluoromethanesulfonate, and a soft nucleophile, such as thioanisole, is described. For disulfide bond formation, two new procedures are presented; the one by oxidation with thallium (III) trifluoroacetate and the other by the acid-catalyzed reaction, involving S-substituted cysteine sulfoxides.