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Orally active aldose reductase inhibitors: indazoleacetic, oxopyridazineacetic, and oxopyridopyridazineacetic acid derivatives

…, WJ Zembrowski, TA Beyer, CE Aldinger…

文献索引:Mylari, Banavara L.; Zembrowski, William J.; Beyer, Thomas A.; Aldinger, Charles E.; Siegel, Todd W. Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2155 - 2162

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被引用次数: 40

摘要

Benzothiazole side chains featured in zopolrestat (la) and ita congeners were incorporated into oxophthalazineacetic acid replacements, including indazole, pyridazinone, and pyridopyridazinone with a pendant acetic acid moiety. Potent aldose reductase inhibition activity among resulting compounds is as widespread as it is in the earlier mpolrestat series, thus lending further support to our hypothesis that there is a binding site on the aldose ...