Study of the chemoselectivity of Grignard reagent addition to substrates containing both nitrile and Weinreb amide functionalities

K Harikrishna, A Rakshit…

文献索引：European Journal of Organic Chemistry, , # 22 p. 4918 - 4932

被引用次数: 5

摘要

... Issue. European Journal of Organic Chemistry. ... at the C-2 position in product 17a is evident from the 1 H NMR spectrum; the C-2 proton in the starting substrate 17 resonates at 4.46 ppm (d, J 2,3 = 2.8 Hz, CHCO), whereas that in the product appears at 4.77 ppm (d, J 2,3 = 2.4 ...

Modeling, synthesis, and biological evaluation of potential ...

[Jurutka, Peter W.; Kaneko, Ichiro; Yang, Joanna; Bhogal, Jaskaran S.; Swierski, Johnathon C.; Tabacaru, Christa R.; Montano, Luis A.; Huynh, Chanh C.; Jama, Rabia A.; Mahelona, Ryan D.; Sarnowski, Joseph T.; Marcus, Lisa M.; Quezada, Alexis; Lemming, Brittney; Tedesco, Maria A.; Fischer, Audra J.; Mohamed, Said A.; Ziller, Joseph W.; Ma, Ning; Gray, Geoffrey M.; Van Der Vaart, Arjan; Marshall, Pamela A.; Wagner, Carl E. Journal of Medicinal Chemistry, 2013 , vol. 56, # 21 p. 8432 - 8454]