N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1

SM Westaway, YK Chung, JB Davis, V Holland…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 16, # 17 p. 4533 - 4536

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被引用次数: 36

摘要

... Bioorganic & Medicinal Chemistry Letters. ... 19. In summary, early lead optimisation chemistry around the HTS lead (3) led to the identification of series of N-tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl carboxamides which showed excellent antagonist potency versus ...