Search of antitubercular activities in tetrahydroacridines: Synthesis and biological evaluation

…, J Pandey, KC Agarwal, V Chaturvedi, YK Manju…

文献索引：Tripathi; Verma; Pandey, Jyoti; Agarwal; Chaturvedi, Vinita; Manju; Srivastva; Gaikwad; Sinha Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 19 p. 5144 - 5147

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被引用次数: 20

摘要

A series of 9-substituted tetrahydroacridines were synthesized by nucleophilic substitution of chloro group with different nucleophiles in 9-chlorotetrahydroacridine (2). The latter could be obtained by POCl3 mediated cyclization of the intermediate enamine, which in turn, was prepared by acid catalyzed condensation of anthranilic acid and cyclohexanone. Most of the compounds on antitubercular evaluation against M. tuberculosis H37 Rv and H37 Ra ...