Antiinflammatory 4, 5-diarylimidazoles as selective cyclooxygenase inhibitors

TE Barta, MA Stealey, PW Collins, RM Weier

文献索引：Barta, Thomas E.; Stealey, Michael A.; Collins, Paul W.; Weier, Richard M. Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 24 p. 3443 - 3448

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被引用次数: 61

摘要

Chemistry It has been recently discovered that the body contains at least two isoforms of cyclooxygenase: COX-1 and COX-2] COX-1 is thought to be involved in normal metabolic housekeeping, for example, cytoprotection of the stomach lining. COX-2 is present in inflamed tissues. Unselective cyclooxygenase inhibitors which disrupt the action of COX-l, such as aspirin and ibuprofen, can lead to stomach ulcers. This effect can be dose limiting in patients with ...