Synthesis of C8-linked pyrrolo [2, 1-c][1, 4] benzodiazepine-acridone/acridine hybrids as potential DNA-binding agents

…, O Srinivas, P Ramulu, G Ramesh, PP Kumar

文献索引：Kamal, Ahmed; Srinivas; Ramulu; Ramesh; Kumar, P. Praveen Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 15 p. 4107 - 4111

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被引用次数: 48

摘要

Therefore, it has been considered of interest to design and synthesize C8-linked PBD-acridone/acridine hybrids that could not only improve the DNA-binding ability but also the biological activity. 18 This is in continuation of our efforts in structural modifications of PBD ring system and also the development of new synthetic strategies 19 for this ring system. We herein report the synthesis and DNA-binding ability of C8-linked acridone/acridine PBD hybrids ...