Synthesis and biological activity of certain alkyl 5-(alkoxycarbonyl)-1H-benzimidazole-2-carbamates and related derivatives: a new class of potential antineoplastic …

S Ram, DS Wise, LL Wotring, JW McCall…

文献索引：Ram; Wise; Wotring; McCall; Townsend Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 539 - 547

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被引用次数: 72

摘要

A series of methyl and ethyl 5-(alkoxycarbonyl)-1H-benzimidazole-2-carbamates (7-19) and methyl 5-carbamoyl-1H-benzimidazole-2-carbamates (24-34) have been synthesized via the reaction of an appropriate alcohol or amine with the acid chloride derivatives 6a or 6b at room temperature. Reaction of an alcohol with acid chloride 6a at reflux temperature afforded transesterified producta 20-23 in good yield. Treatment of methyl 5-amino-lH- ...