Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor …

…, LR Tehrani, DB Wasson, DA Carson

文献索引：Cottam, Howard B.; Shih, Hsiencheng; Tehrani, Lida R.; Wasson, D. Bruce; Carson, Dennis A. Journal of Medicinal Chemistry, 1996 , vol. 39, # 1 p. 2 - 9

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被引用次数: 51

摘要

A series of analogues of pentoxifylline metabolites were prepared in the purine, pteridine,[1, 2, 5] thiadiazolo [3, 4-d] pyrimidine, and quinazoline ring systems and evaluated for their ability to inhibit the production of tumor necrosis factor-α (TNFα) in human peripheral blood monocytes stimulated with bacterial lipopolysaccharide (LPS). The more active compounds were also tested for inhibition of cyclic AMP phosphodiesterase type IV (PDE IV) from ...