Copper-catalyzed intramolecular C− N bond formation: A straightforward synthesis of benzimidazole derivatives in water

…, C Zong, F Hu, L Feng, X Wang, Y Wang…

文献索引：Peng, Jinsong; Ye, Min; Zong, Cuijuan; Hu, Fangyun; Feng, Lingtong; Wang, Xiaoyan; Wang, Yufeng; Chen, Chunxia Journal of Organic Chemistry, 2011 , vol. 76, # 2 p. 716 - 719

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被引用次数: 95

摘要

A straightforward, efficient, and more sustainable copper-catalyzed method has been developed for intramolecular N-arylation providing the benzimidazole ring system. With Cu2O (5 mol%) as the catalyst, DMEDA (10 mol%) as the ligand, and K2CO3 as the base, this protocol was applied to synthesize a small library of benzimidazoles in high yields. Remarkably, the reaction was exclusively carried out in water, rendering the methodology ...