Synthesis of alkyl hydroperoxides via alkylation of gem-dihydroperoxides

SK Kyasa, BW Puffer, PH Dussault

文献索引：Kyasa, Shivakumar; Puffer, Benjamin W.; Dussault, Patrick H. Journal of Organic Chemistry, 2013 , vol. 78, # 7 p. 3452 - 3456

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被引用次数: 9

摘要

A number of methods have been reported for the synthesis of alkyl hydroperoxides,(1) with some of the most widely used based upon displacement of a leaving group by a peroxide nucleophile.(1b, 2) Some years ago, we reported a convenient approach to alkyl hydroperoxides based upon alkylation of 2-methoxypropyl-2-yl hydroperoxide followed by deprotection of the resulting monoperoxyacetals.(3) Although the method has seen significant use,(4) it is ...