Tetrahedron letters

A mild and chemoselective method for the deprotection of tert-butyldimethylsilyl (TBDMS) ethers using iron (III) tosylate as a catalyst

JM Bothwell, VV Angeles, JP Carolan, ME Olson…

文献索引：Bothwell, Jason M.; Angeles, Veronica V.; Carolan, James P.; Olson, Margaret E.; Mohan, Ram S. Tetrahedron Letters, 2010 , vol. 51, # 7 p. 1056 - 1058

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被引用次数: 19

摘要

The most common method for the deprotection of TBDMS ethers utilizes stoichiometric amounts of tetrabutylammonium fluoride, n-Bu4N+ F−(TBAF), which is highly corrosive and toxic. We have developed a mild and chemoselective method for the deprotection of TBDMS, TES, and TIPS ethers using iron (III) tosylate as a catalyst. Phenolic TBDMS ethers, TBDPS ethers and the BOC group are not affected under these conditions. Iron (III) ...