Organic & biomolecular chemistry

Characterization of the TDP-d-ravidosamine biosynthetic pathway: one-pot enzymatic synthesis of TDP-d-ravidosamine from thymidine-5-phosphate and glucose-1- …

MK Kharel, H Lian, J Rohr

文献索引：Kharel, Madan K.; Lian, Hui; Rohr, Juergen Organic and Biomolecular Chemistry, 2011 , vol. 9, # 6 p. 1799 - 1808

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被引用次数: 14

摘要

Ravidomycin V and related compounds, eg, FE35A-B, exhibit potent anticancer activities against various cancer cell lines in the presence of visible light. The amino sugar moieties (D-ravidosamine and its analogues, respectively) in these molecules contribute to the higher potencies of ravidomycin and analogues when compared to closely related compounds with neutral or branched sugars. Within the ravidomycin V biosynthetic gene cluster, five ...