8-Nitroxanthine, an adduct derived from 2'-deoxyguanosine or DNA reaction with nitryl chloride

…, YM Chen, TF Wang, KS Wang, J Shiea

文献索引：Chen, Hauh-Jyun Candy; Chen, Yuan-Mao; Wang, Tze-Fan; Wang, Kuang-Sian; Shiea, Jentaie Chemical Research in Toxicology, 2001 , vol. 14, # 5 p. 536 - 546

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被引用次数: 37

摘要

Activated phagocytic cells generate reactive nitrogen species, including nitryl chloride and peroxynitrite, for host defense against invading pathogens. It has been proposed that these reactive nitrogen species may cause DNA damage and thus contribute to the multistage carcinogenesis process associated with chronic infections and inflammation. Previous studies showed that peroxynitrite reacted with guanine, 2'-deoxyguanosine, or DNA ...